The 23-year-old Cindric slightly beat out Bubba Wallace to win his first career NASCAR Cup Series victory.
Wallace finished second, with Chase Briscoe, Ryan Blaney and Aric Almirola rounding out the top five.
The race was red-flagged with nine laps to go after a wreck involving Kevin Harvick, Kyle Larson and a few other drivers.
Ricky Stenhouse Jr. was the leader during the restart with seven laps to go but crashed into the wall after Brad Keselowski gave him a push from behind.
Three-time Daytona 500 winner Denny Hamlin crashed out of the event for the first time in his career, after getting caught up in an eight-car incident near the end of the opening stage.
The new body styles and components were designed to help curb costs for teams and provide closer racing.